The best choice of Western medicine tablet packagi

2022-07-27
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Reasonable selection of Western medicine tablet packaging materials

western medicine tablet is one of the drug formulations with the largest variety and sales volume at present. As the tablet packaging materials are in direct contact with drugs, they belong to a class of drug packaging. As a special commodity, the drug packaging materials and structural forms must ensure the efficacy of the drugs contained, and ensure the reliable and convenient use of drugs with the continuous appearance of new raw materials, new singers and new products. Therefore, when selecting packaging materials, drug manufacturers should understand some properties and characteristics of packaging materials and containers, so as to reasonably and accurately select pharmaceutical packaging materials in combination with some special requirements of drugs

plastic bottle packaging

in the 1980s, China began to introduce advanced pharmaceutical plastic bottle production lines from abroad and began to replace "glass" with "plastic". The greatest feature of medical plastic bottles is that they are light in weight, not fragile, clean and beautiful. Drug manufacturers can directly use them without cleaning and drying. Moreover, they have excellent chemical resistance, water vapor permeability and sealing performance, which can completely play a role in the safety shielding and protection of the drugs they contain. Medical plastic bottles are made of high density polyethylene (HDPE), polypropylene (PP), polycarbonate (PC) and polyester (PET). In the early 1990s, foreign countries developed a new type of blow molding bottle material polyethylene naphthalate (pen) plastic bottle, which has better properties than pet and is more widely used

at present, medical plastic bottles have many specifications and different shapes. In the face of the brilliant plastic bottle market, drug manufacturers should pay attention to the following principles when selecting plastic bottles: - - select the main raw materials and auxiliary formulas of plastic bottles. High density polyethylene and polypropylene bottles are generally used for tablets. PET bottle can be selected if transparency is required; If the drug needs higher barrier performance, light blocking and opacity, the brown PET bottle shall be selected; Pen bottle has the best barrier performance

-- pay attention to the tightness and water vapor permeability of the bottle body and cap. Sealing and water vapor permeability are two important technical indicators of medical plastic bottles. They have a great impact on the stability of drugs

-- pay attention to the product quality standards of plastic bottles. From the product quality standard, we can analyze and judge the product quality

-- inspect the quality assurance system. The audit of suppliers has become an essential part of the purchase of plastic bottles. Through audit, the comprehensive level of software and hardware facilities, technical equipment and quality of the manufacturer can be comprehensively and correctly assessed

-- test the charge stability and compatibility of plastic bottles. When selecting plastic bottles, especially new plastic bottles (or new materials and new processes) for new drugs, charge tests should be carried out first to investigate the charge stability and the compatibility between plastic bottles and drugs

blister packaging

blister packaging of drugs is also called blister eye packaging. Compared with bottled tablet drugs, the biggest advantage of blister packaging is that it is easy to carry and can reduce the pollution in the process of carrying and taking drugs. However, it is said that the unit cost of blister packaging is significantly higher than that of bottled drugs when long-term drug users are tested under high temperature and high humidity for 1000 hours at 85 ℃ and 85%rh. Therefore, some pharmaceutical enterprises usually choose blister packaging for high price, high technical content and new varieties of drugs. The domestic and foreign experimental machine manufacturers of this Packaging Institute are actively researching and developing the materials mainly used for medical aluminum foil and plastic hard sheet (PTP). Medical aluminum foil is a sealing material sealed on plastic hard sheet. It takes hard industrial pure aluminum as the base material, and has the characteristics of non-toxic, corrosion-resistant, impermeable, heat resistant, moisture-proof, light resistant and high-temperature sterilization. PVC, PVDC or composite materials are usually used as hard plastic sheet materials, which have good barrier properties to water, steam and light

if pharmaceutical enterprises want to select pharmaceutical aluminum foil packaged tablet products, when signing the PTP aluminum foil purchase contract with the supplier, they must specify the relevant technical requirements, such as product name, specification (width and thickness requirements), printing color, aluminum foil roll text arrangement direction and position, aluminum foil structure, adhesive coating amount, coating color requirements, packaging requirements, etc

there are also certain principles for the selection of medicinal plastic hard tablets or composite materials: PVC hard tablets can be used for ordinary tablet drugs that do not have high requirements for moisture resistance; For drugs with moisture-proof and anti-oxidation requirements or with long shelf life requirements, pet hard tablets and PP hard tablets can be selected

certain procedures shall be followed in selecting hard disk materials: when selecting polymer hard disk according to drug properties and shelf life requirements, technical experts of drug packaging material manufacturers shall be consulted or material tests shall be carried out, and equipment universality, appearance novelty and cost minimization shall be fully considered; Machine test shall be carried out to determine the applicability of drug packaging materials to the equipment and the satisfaction of product quality and appearance; Each drug must be tested for stability and compatibility, because the properties of various drugs are different; It is necessary to go to the drug packaging material enterprise to review the environment, equipment, process, quality and other related management contents, and jointly determine the raw materials, formula, structure and product standards of drug packaging materials with it, and finally sign an agreement

strip composite film packaging

some large dosage forms or drug tablets that are sensitive to ultraviolet light, have strong hygroscopicity, require heat and cold resistance and long validity period, and require to improve the packaging grade, should adopt strip composite film packaging, referred to as SP for short. It uses two layers of medicinal strip packaging film (SP film) to clamp the tablets in the middle, and the unit drugs are separated by a certain distance. On the strip packaging machine, the inner sides of the two layers of SP film around the drugs are heat sealed, and the tooth marks are pressed between the drugs to form the unit packaging form (single-chip packaging or rows of small packaging). This kind of packaging needs continuous operation on the strip packaging machine, which is especially suitable for automatic packaging in large quantities. When taking medicine, tear the SP film along the tooth mark. The strip packaging film has a certain tensile strength and elongation, which is suitable for drugs of various shapes and sizes. After packaging, it is close to the drugs inside, and is not easy to produce cracks and wrinkles. At present, aluminum-plastic composite films are widely used, such as cellophane and aluminum foil and polyethylene (Pt/Al/PE), polyester and aluminum foil and polyethylene (PET/Al/PE), that is, aluminum foil and plastic film are laminated or extruded by adhesive. They are composed of base layer, printing layer, high resistance barrier layer and sealing layer. The base layer is outside, the sealing layer is inside, and the high resistance barrier layer and printing layer are in the middle. The base course materials shall have excellent mechanical properties, gloss, good printability, good transparency, high barrier performance, safety, non toxicity and no sealing. Typical materials include polyester (PET), cellophane (PT) and cellophane with PVDC coating. The high resistance barrier layer requires good gas barrier performance and moisture resistance, will not pass through bacteria and microorganisms, good mechanical performance, certain elongation, cold and heat resistance, safety and non-toxic. Its typical material is soft aluminum foil. Soft aluminum foil is generally opaque, does not rust, and has strong shading. If transparent strip packaging film is required, PVDC shall be used as high resistance barrier material, which is characterized by excellent barrier performance against gas and water vapor. The sealing layer is the inner layer of strip packaging film, which has excellent sealing performance, chemical stability, safety and hygiene. It is generally made of low-density polyethylene

when pharmaceutical enterprises choose composite film for packaging, it shall be determined according to drug properties (damp, oxidation, drug flavor retention, etc.) and shelf life. The following points can be used for reference:

-- the composite structure of the common composite film is PET/Al/PE, which is characterized by good printing adaptability and good gas and water barrier to drugs

-- the composite structure of the medicinal strip easy to tear composite film is Pt/PE/Al/PE, which is characterized by good tear resistance and convenient access to products by consumers. Its good gas and water vapor barrier can also ensure that the content has a long shelf life

-- the composite structure of paper aluminum plastic composite film is paper/PE/Al/PE, which is characterized by good stiffness and is suitable for printing. In addition, it has good barrier performance to gas or water, which can make the drug have a long shelf life

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